On some descriptive and predictive methods for the dynamics of cancer growth


  • Iulian T. Vlad University Jaume I of Castellón
  • Jorge Mateu University Jaume I of Castellón
  • Elvira Romano Seconda Università degli Studi di Napoli, Caserta




Geometric methods, Prediction methods, Space-time modeling, Tumor growth


Cancer is a widely spread disease that affects a large proportion of the human population, and many research teams are developing algorithms to help medics to understand this disease. In particular, tumor growth has been studied from different viewpoints and several mathematical models have been proposed. In this paper, we review a set of comprehensive and modern tools that are useful for prediction of cancer growth in space and time. We comment on three alternative approaches. We first consider spatio-temporal stochastic processes within a Bayesian framework to model spatial heterogeneity, temporal dependence and spatio-temporal interactions amongst the pixels, providing a general modeling framework for such dynamics. We then consider predictions based on geometric properties of plane curves and vectors, and propose two methods of geometric prediction. Finally we focus on functional data analysis to statistically compare tumor contour evolutions. We also analyze real data on brain tumor.


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How to Cite

Vlad, I. T., Mateu, J., & Romano, E. (2015). On some descriptive and predictive methods for the dynamics of cancer growth. Statistica, 75(3), 247–263. https://doi.org/10.6092/issn.1973-2201/6096